How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?
نویسندگان
چکیده
منابع مشابه
Targeting of several glycolytic enzymes using RNA interference reveals aldolase affects cancer cell proliferation through a non-glycolytic mechanism.
In cancer, glucose uptake and glycolysis are increased regardless of the oxygen concentration in the cell, a phenomenon known as the Warburg effect. Several (but not all) glycolytic enzymes have been investigated as potential therapeutic targets for cancer treatment using RNAi. Here, four previously untargeted glycolytic enzymes, aldolase A, glyceraldehyde 3-phosphate dehydrogenase, triose phos...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2014
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2014.320